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帕金森病(parkinson’s disease,PD)是一种好发于中老年人的神经系统疾病,是继阿尔茨海默病后第二常见的神经退行性疾病。帕金森病的主要病理特征为中脑黑质致密区多巴胺能神经元进行性变性坏死,甚至缺失,导致黑质纹状体通路多巴胺(DA)神经递质的减少。PD的致病机理复杂,目前认为该病是由遗传、环境、年龄老化等因素共同作用的结果,其具体机制可能涉及线粒体功能障碍、氧化应激、神经炎症等多方面。本文拟就近年来PD发病机制方面的研究作一综述。
Abstract：Parkinson's disease(PD) is a neurological disease that occurs in middle-aged and elderly people and is the second most common neurodegenerative disease after Alzheimer's disease. The main pathological feature of Parkinson's disease is progressive degeneration and necrosis of dopaminergic neurons in the substantia nigra pars compacta, resulting in a decrease in dopaminergic(DA) neurotransmitters in the nigrostriatal pathway. The pathogenesis of PD is complex. It is currently believed to be the result of genetic, environmental, and ageing factors. The specific mechanism may involve mitochondrial dysfunction, oxidative stress, and neuroinflammation. This article is intended to review the research on the pathogenesis of PD in recent years.
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基本信息:
中图分类号:R742.5
引用信息:
[1]游静,顾乔乔,余子云,等.帕金森病发病机制的研究进展[J].赣南医学院学报,2019,39(07):733-737.
基金信息:
国家创新创业训练项目(NO.201810413009); 赣南医学院本科生科技创新项目(NO.XS201723);赣南医学院校级重点项目(NO.ZD201807);赣南医学院校级一般项目(NO.YB201817)
2019-07-28
2019-07-28