虞子宁,张丽梅,黄志华,李良东

• 1:赣南医学院
• 2:赣南医学院心脑血管疾病防治教育部重点实验室
• 3:赣南医学院第一附属医院

摘要(Abstract)：

缺血性脑卒中发生时,缺血缺氧会触发一系列事件,包括炎症反应、兴奋毒性、氧化应激和细胞程序性死亡,从而导致严重的脑损伤。缺血区星形胶质细胞活化,表现出两种不同的功能表型,即以炎症刺激为主诱导的神经毒性A1型星形胶质和缺血诱导的神经保护性A2型反应性星形胶质。A1型星形胶质细胞通过产生和释放促炎因子、趋化因子和神经毒性介质,使细胞存活、增殖、分化等功能紊乱,A2型星形胶质细胞通过其吞噬功能以及释放神经营养因子和神经源性转录因子发挥神经保护作用。因此,通过调节A1/A2反应性星形胶质细胞的激活,既可以减小毒性作用,又可以加强保护作用。本文讨论了星形胶质细胞的功能以及A1/A2反应性星形胶质细胞在缺血性脑卒中的作用,为如何减少星形胶质细胞的不利影响和放大星形胶质细胞对神经保护提供新思路,也为临床脑卒中治疗提供新策略。

关键词(KeyWords)： 缺血性脑卒中;反应性星形胶质细胞;神经毒性;神经保护

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81760654,31960190);; 心脑血管疾病防治教育部重点实验室开放课题(XN201811);; 江西省自然科学基金项目(20192BAB205117);; 江西省教育厅科技项目(GJJ160968);; 赣南医学院创新团队项目(TD20170)

作者(Author): 虞子宁,张丽梅,黄志华,李良东

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